2024
251. "In vitro discovery of a therapeutic lead for HFMD from a library screen of rocaglates/aglains" Oo, A.; Borge, A.; Lee, R. C. H.; Salim, C. K.; Wang, W.; Ricca, M.; Fong, D. Y.; Alonso, S.; Brown, L. E.; Porco, J. A., Jr.; Chu, J. J. H. bioRxiv Full Text
250. "Evolution of a Strategy for the Unified, Asymmetric Total Syntheses of DMOA-Derived Spiromeroterpenoids" Yang, F.; Oladokun, A.; Porco, J. A., Jr. J. Org. Chem. 2024, 89, 17, 11891–11908. Full Text
249. "Amidino-Rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis" Keiser, P. T.; Zhang, W.; Ricca, M.; Wacquiez, A.; Grimins, A.; Cencic, R.; Patten, J. J.; Shah, P.; Padilha, E.; Connor, J. H.; Pelletier, J.; Lyons, S. M.; Saeed, M.; Brown, L. E.; Porco, J. A., Jr.; Davey, R. A. Antiviral Res. 2024, 105976. Full Text
248. "Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells" Wang, Z.; Thakare, R. P.; Chitale, S.; Mishra, A. K.; Goldstein, S. I.; Fan, A. C.; Li, R.; Zhu, L. J.; Brown, L. E.; Cencic, R.; Huang, S.; Green, M. R.; Pelletier, J.; Malonia, S. K.; Porco, J. A., Jr. ACS Cent. Sci. 2024, 10, 8, 1640–1656. Full Text
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247. "Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes" Thirman, H. L.; Hayes, M. J.; Brown, L. E.; Porco, J. A., Jr.; Irish, J. M. bioRxiv Full Text
246. "The MYCN 5′ UTR as a therapeutic target in neuroblastoma" Volegova, M.P.; Brown, L.E.; Banerjee, U.; Dries, R.; Sharma, B.; Kennedy, A.; Porco, J.A, Jr.; George RE. Cell Rep., 2024, 43 (5), 114134, Full Text
245. "Proteomic Discovery of RNA-Protein Molecular Clamps Using a Thermal Shift Assay with ATP and RNA (TSAR)" Goldstein, S.I.; Fan, A.C.; Wang, Z; Naineni, S.K.; Lengqvist, J.; Chernobrovkin, A.; Garcia-Gutierrez, S.B.; Cencic, R.; Patel, K.; Huang, S; Brown, L.E.; Emili, A; Porco, J.A, Jr., bioRxiv Full Text
244. "Triple-Dearomative Photocycloaddition – A Strategy to Construct Novel Caged Molecular Frameworks." Ji, K; Parthiban, J; Jockusch, S; Sivaguru, J; Porco, J.A, Jr., J. Am. Chem. Soc. 2024, 146 (19), 13445–13454 Full Text
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243. "A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen Candida albicans." Fallah, S.; Duncan, D.; Reichl, K. D.; Smith, M. J.; Wang, W.; Porco, J. A., Jr.; Brown, L. E.; Whitesell, L.; Robbins, N.; Cowen, L. E., Microbiol. Spectr. 2024, 12 (4), e0409523, Full Text
242. “Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt" Ji, K.; Johnson, P.R.; McNeely, J.; Al Faruk, M.; Porco, J. A., Jr.. J. Am. Chem. Soc. 2024, 146 (7), 4892–4902 Full Text
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2023
241. “Synthesis of Neocannabinoids Using Controlled Friedel–Crafts Reactions" Millimaci, A. M.; Trilles, R. V.; McNeely, J. H.; Brown, L. E.; Beeler, A. B.; Porco, J. A., Jr. J. Org. Chem. 2023, 88, 18, 13135–13141 Full Text
240. “Exploring the Targeting Spectrum of Rocaglates Among eIF4A Homologs" Naineni, S.K., Cencic, R., Robert, F., Brown, L., Haque, M., Scott-Talib, J., Senechal, P., Schmeing, T.M., Porco, J., Jr., and Pelletier, J. RNA 2023, 29(6):826-835. Full Text
2022
239. “BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling" Shaashua, L.; Ben-Shmuel, A.; Pevsner-Fischer, M.; Friedman, G.; Levi-Galibov, O.; Nandakumar, S.; Barki, D.; Nevo, R.; Brown, L. E.; Zhang, W.; Stein, Y.; Lior, C.; Kim, H. S.; Bojmar, L.; Jarnagin, W. R.; Lecomte, N.; Mayer, S.; Stok, R.; Bishara, H.; Hamodi, R.; Levy-Lahad, E.; Golan, T.; Porco, J. A.; Iacobuzio-Donahue, C. A.; Schultz, N.; Tuveson, D. A.; Lyden, D.; Kelsen, D.; Scherz-Shouval, R., Nat Commun 2022, 13 (1), 6513. Full Text
237. “Inhibition of the translation initiation factor eIF4A enhances tumor cell radiosensitivity." Lehman, S. L.; Wechsler, T.; Schwartz, K.; Brown, L. E.; Porco, J. A.; Devine, W. G.; Pelletier, J.; Shankavaram, U. T.; Camphausen, K.; Tofilon, P. J., Mol. Cancer. Ther. 2022,0037 Full Text
236. “Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication." Praditya, D. F.; Klöhn, M.; Brüggemann, Y.; Brown, L. E.; Porco, J. A.; Zhang, W.; Kinast, V.; Kirschning, A.; Vondran, F. W. R.; Todt, D.; Steinmann, E., Antiviral Research. 2022, 204, 105359. Full Text
2021
235. “Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates." Wenqing, Xu, Brown, L.E., and Porco, J.A., J. Org. Chem. 2021, 86 (23), 16485-16510. Full Text
234. “A forward genetic screen identifies modifiers of rocaglate responsiveness." Shen, L., Pugsley, L., Cencic, R., Wang, H., Robert, F., Naineni, S.K., Sahni, A., Morin, G., Zhang, W., Nijnik, A. and Porco, J.A., Jr, Langlais, D., Huang, S., & Pelletier, J., Scientific Reports 2021, 11(1), pp.1-13. Full Text
233. “Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis." Chatterjee, S., Yabaji, S.M., Rukhlenko, O.S., Bhattacharya, B., Waligurski, E., Vallavoju, N., Ray, S., Kholodenko, B.N., Brown, L.E., Beeler, A.B., Ivanov, A.R., Kobzik, L., Porco, J. A., Jr, & Kramnik, I. iScience 2021, 102845. Full Text
232. “Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML." Nishida, Y., Zhao, R., Heese, L. E., Akiyama, H., Patel, S., Jaeger, A. M., Jacamo, R. O., Kojima, K., Ma, M., Ruvolo, V. R., Chachad, D., Devine, W., Lindquist, S., Davis, R. E., Porco, J. A., Jr, Whitesell, L., Andreeff, M., & Ishizawa, J. Leukemia 2021, 1-13.
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231. “Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma." Skofler, C.; Kleinegger, F.; Krassnig, S.; Birkl-Toeglhofer, A. M.; Singer, G.; Till, H.; Benesch, M.; Cencic, R.; Porco, J. A., Jr.; Pelletier, J.; Castellani, C.; Raicht, A.; Izycka-Swieszewska, E.; Czapiewski, P.; Haybaeck, J. Cells 2021, 10, 301.
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230. “Synthesis and Multiplexed Activity Profiling of Synthetic Acylphloroglucinol Scaffolds." Boyce, J. H.; Reisman, B.; Bachmann, B. O.; Porco, J. A., Jr. Angew. Chem., Int. Ed. 2021, 60, 1263–1272.
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2020
229. “An Oxindole Efflux Inhibitor Potentiates Azoles and Impairs Virulence in the Fungal Pathogen Candida auris." Iyer, K. R.; Camara, K.; Daniel-Ivad, M.; Trilles, R.; Pimentel-Elardo, S. M.; Fossen, J. L.; Marchillo, K.; Liu, Z.; Singh, S.; Muñoz, J. F.; Kim, S. H.; Porco, J. A., Jr.; Cuomo, C. A.; Williams, N. S.; Ibrahim, A. S.; Edwards, J. E., Jr.; Andes, D. R.; Nodwell, J. R.; Brown, L. E.; Whitesell, L.; Robbins, N.; Cowen, L. E. Nat. Commun. 2020, 11, 6429.
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228. “Heat Shock Factor 1-Dependent Extracellular Matrix Remodeling Mediates the Transition from Chronic Intestinal Inflammation to Colon Cancer." Levi-Galibov, O.; Lavon, H.; Wassermann-Dozorets, R.; Pevsner-Fischer, M.; Mayer, S.; Wershof, E.; Stein, Y.; Brown, L. E.; Zhang, W.; Friedman, G.; Nevo, R.; Golani, O, Katz, L. H.; Yaeger, R.; Laish, I.; Porco, J. A.; Sahai, E.; Shouval, D. S.; Kelsen, D.; Scherz-Shouval, R. Nat. Commun. 2020, 11, 6245.
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227. “Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids." Abe, I.; Mitsuhashi, T.; Barra, L.; Powers, Z.; Kojasoy, V.; Cheng, A.; Yang, F.; Taniguchi, Y.; Kikuchi, T.; Fujita, M.; Tantillo, D. J.; Porco, J. A., Jr. Angew. Chem., Int. Ed. 2020, 59, 23980–23989.
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226. “Acylphloroglucinols with acetylcholinesterase inhibitory effects from the fruits of Eucalyptus robusta." Liu, H.; He, X.-Z.; Feng, M.-Y.; Zeng, Y.; Rauwolf, T. J.; Shao, L.-D.; Ni, W.; Yan, H.; Porco, J. A., Jr.; Hao, X.-J.; Qin, X.-J.; Liu, H.-Y. Bioorg. Chem. 2020, 103, 104127.
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225. “Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris." Iyer, K. R.; Whitesell, L.; Porco, J. A., Jr.; Henkel, T.; Brown, L. E.; Robbins, N.; Cowen, L. E. mBio Mar 2020, 11 (2) e03329-19.
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224. “Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F." Chu, J.; Zhang, W.; Cencic, R.; O’Connor, P. B. F.; Robert, F.; Devine, W. G.; Selznick, A.; Henkel, T.; Merrick, W. C.; Brown, L. E.; Baranov, P. V.; Porco, J. A., Jr.; Pelletier, J. Cell Reports 2020, 30, 2481–2488.
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2019
223. “eIF4A Supports an Oncogenic Translation Program in Pancreatic Ductal Adenocarcinoma." Chan, K.; Robert, F.; Oertlin, C.; Kapeller-Libermann, D.; Avizonis, D.; Gutierrez, J.; Handly-Santana, A.; Doubrovin, M.; Park, J.; Schoepfer, C.; Da Silva, B.; Yao, M.; Gorton, F.; Shi, J.; Thomas, C. J.; Brown, L. E.; Porco, J. A., Jr.; Pollak, M.; Larsson, O.; Pelletier, J.; Chio, I. I. C. Nat. Commun. 2019, 10, 5151.
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222. “Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors." Chu, J.; Zhang, W.; Cencic, R.; Devine, W. G.; Beglov, D.; Henkel, T.; Brown, L. E.; Vajda, S.; Porco, J. A., Jr.; Pelletier, J. Cell Chem. Biol. 2019, 26, 1586–1593.
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221. “Biomimetic Synthesis of Meroterpenoids by Dearomatization‐Driven Polycyclization." Powers, Z.; Scharf, A.; Cheng, A.; Yang, F.; Himmelbauer, M.; Mitsuhashi, T.; Barra, L.; Taniguchi, Y.; Kikuchi, T.; Fujita, M.; Abe, I.; Porco, J. A., Jr. Angew. Chem. Int. Ed. 2019, 58, 16141-16146.
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220. “Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity." Gonçalves, A. C.; Towers, E. R.; Haq, N.; Porco, J. A., Jr.; Pelletier, J.; Dawson, S. J.; Gale, J. E. Sci. Rep. 2019, 12501.
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219. “Gold(I)-Mediated Cycloisomerization/Cycloaddition Enables Bioinspired Syntheses of Neonectrolides B-E and Analogs." Purgett, T. J.; Dyer, M. W.; Bickel, B,; McNeely, J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2019, 141, 15135-15144.
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218. “eIF4A Inhibitors Suppress Cell Cycle Feedback Response and Acquired Resistance to CDK4/6 Inhibition in Cancer." Kong, T.; Xue, Y.; Cencic, R.; Zhu, X.; Monast, A.; Fu, Z., Pilon, V.; Sangwan, V.; Guiot, M.-C.; Foulkes, W. D.; Porco, J. A., Jr.; Park, M.; Pelletier, J.; Huang, S. Mol. Cancer Ther. 2019, Pblished Online First: August 8, 2019. (doi: 10.1158/1535-7163.MCT-19-0162)
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217. “Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors." Zhang, W.; Chu, J.; Cyr, A. M.; Yueh, H.; Brown, L. E.; Wang, T. T.; Pelletier, J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2019, 141, 12891-12900.
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216. “Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (–)-Nemorosone and (–)-6-epi-Garcimultiflorone A." Wen, S.; Boyce, J. H.; Kandappa, S. K.; Sivaguru, J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2019, 141, 11315-11321.
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215. “Targeting Translation Initiation by Synthetic Rocaglates for Treating MYC-Driven Lymphomas." Zhang, X.; Bi, C.; Lu, T.; Zhang, W.; Yue, T.; Wang, C.; Tian, T.; Zhang, X.; Huang, Y.; Lunning, M.; Hao, X.; Brown, L. E.; Devine, W. G.; Vose, J.; Porco, J. A., Jr.; Fu, K. Leukemia 2019, Published Online: June 06, 2019.
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214. “Tracing MYC Expression for Small Molecule Discovery." Steinberger, J.; Robert, F.; Halle, M.; Williams, D.; Cencic, R.; Sawhney, N.; Pelletier, D.; Williams, P.; Igarashi, Y.; Porco, J. A., Jr.; Rodriguez, A. D.; Kopp, B.; Bachmann, B.; Andersen, R. J.; Pelletier, J. Cell. Chem. Bio, 2019, 26, 1-12.
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213. “Small Molecule Amyloid Protein Precursor Processing Modulators Lower Amyloid Peptide Levels via cKit Signaling." Chen, C. D.; Zeldich, E.; Khodr, C.; Camara, K.; Tung, T. Y.; Lauder, E. C.; Mullen, P.; Polanco, T. J.; Liu, Y. Y.; Zeldich, D.; Xia, W.; Van Nostrand, W. E.; Brown, L. E.; Porco, J. A., Jr.; Abraham, C. R. J. Alzheimers Dis. 2019, 67, 1089.
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212. “Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation." Maiga, R. I.; Cencic, R.; Chu, J.; Waller, D. D.; Brown, L. E.; Devine, W. G.; Zhang, W.; Sebag, M.; Porco, J. A., Jr.; Pelletier, J. Sci. Rep. 2019, 1265.
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211. “Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate." Qin, X.-J.; Rauwolf, T. J.; Li, P.-P.; Liu, H.; McNeely, J.; Hua, Y.; Liu, H.-Y.; Porco, J. A., Jr. Angew. Chem. Int. Ed. 2019, 58, 4291.
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210. “Structural Basis for Species-Selective Targeting of Hsp90 in a Pathogenic Fungus." Whitesell, L. et. al. Nat. Commun. 2019, 10, 402.
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209. “Discovery of Macrocylic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1." Trilles, R.; Beglov, D.; Chen, Q.; He, H.; Wireman, R.; Reed, A.; Chennamadhavuni, S.; Panek, J. S.; Brown, L. E.; Vajda, S.; Porco, J. A., Jr.; Kelley, M. R.; Georgiadis, M. M. J. Med. Chem. 2019, 62, 1971.
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208. “METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis." Liu, S. et. al. Cell 2019, 176, 1-14.
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207. “Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection." Zhang, W.; Liu, S.; Maiga, R. I.; Pelletier, J.; Brown, L. E.; Wang, T. T.; Porco, J. A., Jr. J. Am. Chem. Soc. 2019, 141, 1312. Featured in Synfacts 2019, 15, 433.
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206. “Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition." Smith, M. J.; Reichl, K. D.; Escobar, R. A.; Heavey, T.; Coker, D. F.; Schaus, S. E.; Porco, J. A., Jr. J. Am. Chem. Soc. 2019, 141, 148-153.
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2018
205. “Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space." Kearney, S. E. et. al. ACS Cent. Sci. 2018, 4, 1727-1741.
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204. “Sensitization of Renal Carcinoma Cells to TRAIL-induced Apoptosis by Rocaglamide and Analogs." Nalli, A. D.; Brown, L. E.; Thomas, C. L.; Sayers, T. J.; Porco, J. A., Jr.; Henrich, C. J. Sci. Rep. 2018, article number:17519.
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203. “Diastereodivergent Synthesis of Chiral Tetrahydropyrrolodiazepinediones via a one-pot Intramolecular Aza-Michael/lactamization Sequence." Chennamadhavuni, S.; Panek, J. S.; Porco, J. A. Jr.; Brown, L. E. J. Org. Chem.. 2018, 83, 15449-15462.
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202. “Eucalyptusdimers A−C, Dimeric Phloroglucinol−Phellandrene Meroterpenoids from Eucalyptus robusta." Qin, X.-J.; Feng, M.-Y.; Liu, H.; Ni, W.; Rauwolf, T.; Porco, J. A. Jr..; Yan, H.; He, L.; Liu, H.-Y. A. Org. Lett. 2018, 20, 5066-5070.
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201. “High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics." Yang, X.; Jounaidi, Y.; Dai, J. B.; Marte-Oquendo, F.; Halpin, E. S.; Brown, L. E.; Trilles, R.; Xu, W.; Daigle, R.; Schaus, S. E.; Porco, J. A., Jr., Forman, S. A. Anesthesiology 2018, 129, 459.
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200. “Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling." Wu, X.; Iwata, T.; Scharf, A.; Qin, T.; Reichl, K. D.; Porco, J. A., Jr. J. Am. Chem. Soc. 2018, 140, 5969-5975.
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199. “Rocaglates as Dual-Targeting Agents for Experimental Cerebral Malaria." Langlais, D.; Cencic, R.; Moradin, N.; Kennedy, J. M.; Ayi, K.; Brown, L. E.; Crandall, I.; Tarry, M. J.; Schmeing, M.; Kain, K. C.; Porco, J. A., Jr., Pelletier, J.; Gros, P. Proc. Natl. Acad. Sci. 2018, 115, E2366.
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198. “Total Synthesis of Aurofusarin: Studies on the Atropisomeric Stability of Bis-Naphthoquinones." Qi, C.; Wang, W.; Reichl, K. D.; McNeely, J.; Porco, J. A., Jr. Angew. Chem. Int. Ed. 2018, 57, 2101-2104.
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2017
197. “Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B: Selective Excited-State Intramolecular Proton-Transfer Photocycloaddition." Wang, W.; Clay, A.; Krishnan, R.; Lajkiewicz, N. L.; Brown, L. E.; Sivaguru, J.; Porco, J. A., Jr. Angew. Chem. Int. Ed. 2017, 56, 14479-14482.
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196. “Biomimetic Total Synthesis of (+/-)-Griffipavixanthone via a Cationic Cycloaddition-Cyclization Cascade.” Reichl, K. D.; Smith, M. J.; Song, M. K.; Johnson, R. P.; Porco, J. A., Jr. J. Am. Chem. Soc. 2017, 139, 14053-14056.
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195. “A Photochemical Flow Reactor for Large Scale Syntheses of Aglain and Rocaglate Natural Product Analogues.” Yueh, H.; Gao, Q., Porco, J. A., Jr.; Beeler, A. B. Bioorg. Med. Chem. 2017, 25 ,6197-6202.
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194. “Inhibiting the Oncogenic Translation Program is an Effective Therapeutic Strategy in Multiple Myeloma.” Manier, S.; Huynh, D.; Shen, Y. J.; Zhou, J.; Yusufzai, T.; Salem, K. Z.; Ebright, R. Y.; Shi, J.; Park, J.; Glavey, S. V.; Devine, W. G.; Liu, C.-J.; Leleu, X.; Quesnel, B.; Roche-Lestienne, C.; Snyder, J. K.; Brown, L. E.; Gray, N.; Bradner, J.; Whitesell, L.; Porco, J. A., Jr.; Ghobrial, I. M. Sci. Transl. Med. 2017, 9, eaal2268.
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2016
193. “Syntheses of (+)-30-epi-, (-)-6-epi-, (+/-)-6,30-epi-13,14-Didehydroxyisogarcinol, and (+/-)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis-Acid Controlled Cyclizations.” Boyce, J. H.; Eschenbrenner-Lux, V.; Porco, J. A., Jr. J. Am. Chem. Soc. 2016, 138, 14789-14797.
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192. “Development of a Potent and Selective HDAC8 Inhibitor.” Ingham, O. J.; Paranal, R. M.; Smith, W. B.; Escobar, R. A.; Yueh, H.; Snyder, T.; Porco, J. A., Jr.; Bradner, J. E.; Beeler, A. B. ACS Med. Chem. Lett. 2016, 7, 929-932.
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191. “Asymmetric Dearomatization/ Cyclization Enables Access to Novel Chemotypes.” Hayashi, M.; Brown, L. E.; Porco, J. A., Jr. Eur. J. Org. Chem. 2016, 28, 4800-4804.
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190. “Synthesis of Aza-Rocaglates via ESIPT-mediated (3+2) Photocycloaddition.” Wang, W.; Cencic, R.; Whitesell, L.; Pelletier, J.; Porco, J. A., Jr. Chem. Eur. J. 2016, 22, 12006-12010.
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189. “CRISPR-Mediated Drug Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A.” Chu, J.; Galicia-Vazquez, G.; Cencic, R.; Mills, J. R.; Katigbak, A.; Porco, J. A., Jr.; Pelletier, J. Cell Reports 2016, 15, 2340-2347.
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188. “Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis.” Kaerkaes, M. D.; Porco, J. A., Jr.; Stephenson, C. R. J. Chem. Rev. 2016, 116, 9683-9747.
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187. “Fine-tuning of Macrophage Activation Using Synthetic Rocaglate Derivatives.” Bhattacharya, B.; Chatterjee, S.; Devine, W. G.; Kobzik, L.; Beeler, A. B.; Porco, J. A., Jr.; Kramnik, I. Scientific Reports 2016, 6, 24409.
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186. “NanoCAGE Reveals 5’UTR Features That Define Specific Modes of Translation of Functionally Related mTOR-Sensitive mRNAs.” Gandin, V.; Masvidal, L.; Hulea, L.; Gravel, S.-P.; Cargnello, M.; McLaughlan, S.; Cai, Y.; Balanathan, P.; Morita, M.; Rajakumar, A.; Furic, L.; Pollak, M.; Porco, J. A., Jr.; St-Pierre, J.; Pelletier, J.; Larsson, O.; Topisirovic, I. Genome Res. 2016, 26, 636-648.
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185. “Asymmetric Syntheses of the Flavonoid Diels-Alder Natural Products Sanggenons C and O.” Qi, C.; Xiong, Y.; Eschenbrenner-Lux, V.; Cong, H.; Porco, J. A., Jr., J. Am. Chem. Soc. 2016, 138, 798-801.
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184. “Translation Inhibition by Rocaglates is Independent of eIF4E Phosphorylation Status.” Chu, J.; Cencic, R.; Wang, W.; Porco, J.A., Jr.; Pelletier, J., Mol. Cancer. Ther. 2016, 15, 136-141.
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2015
183. Porco, J. A., Jr.; Boyce, J. “Intermolecular Alkylative Dearomatization of Phenolic Derivatives in Organic Synthesis, ” Science of Synthesis (SOS), Applications of Domino Transformations in Organic Synthesis; Snyder, S. A., Ed.; Thieme: New York, 2015. Vol. 1, pp 229-291.
182. “Synthesis of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of “Shapeshifting” Properties.” Qin, T.; Iwata, T.; Ransom, T.T. Beutler, J.A.; Porco, J.A., Jr. J. Am. Chem. Soc. 2015, 137, 15225-15233.
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181. “A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway.” Liu, S.; Wang, W.; Brown, L.E.; Qiu, C.; Lajkiewicz, N.; Zhao, T.; Zhou, J.; Porco, J.A., Jr.; Wang, T.T. EBioMedicine, 2015, 2, 1600-1606.
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180. “Divergent Total Syntheses of Rhodomyrtosones A and B.” Gervais, A.; Lazarski, K.E.; Porco, J.A., Jr., J. Org. Chem. 2015, 80, 9584-9591.
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179. “Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines.” Yeo, A.T.; Chennamadhavuni, S.; Whitty, A.; Porco, J.A., Jr.; Gilmore, T.D., Molecules 2015, 20, 7474-7494.
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178. “Atropselective Syntheses of (-) and (+) Rugulotrosin A Utilizing Point-to-Axial Chirality Transfer.” Qin, T.; Skraba-Joiner, S.L.; Khalil, Z.G.; Johnson, R.P.; Capon, R.J.; Porco, J.A., Jr. Nat. Chem. 2015, 7, 234-240.
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177. “Biomimetic Kinetic Resolution: Highly Enantio- and Diastereoselective Transfer Hydrogenation of Aglain Ketones To Access Flavagline Natural Products.” Stone, S.D.; Lajkiewicz, N.J.; Whitesell, L.; Hilmy, A.; Porco, J.A., Jr. J. Am. Chem. Soc. 2015, 137, 525-530.
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2014
176. “Thiourea-Catalyzed Enantioselective Addition of Indoles to Pyrones: Alkaloid Cores with Quaternary Carbons.” Yeung, C.S.; Ziegler, R.E.; Porco, J.A., Jr.; Jacobsen, E.N. J. Am. Chem. Soc. 2014, 136, 13614-13617.
175. “Identification of a novel polyprenylated acylphloroglucinol-drived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities.” Zhu, L.; Qi J.; Chiao, C.Y.; Zhang, Q.; Porco, J.A., Jr.; Faller, D.V.; Dai, Y. J Oncol. 2014, 2128-2136.
174. “Translation initiaion factor elF4F modifies the dexamethasone response in multiple myeloma.” Robert, F.; Roman, W.; Bramoullé, F.; Fellmann, C.; Roulston, A.; Shustik, C.; Porco, J. A., Jr.; Shore, G.C.; Sebag, M.; Pelletier, J., PNAS 2014, 11, 13421-13426.
173. “RNA G-quadruplexes cause elF4A-dependent oncogene translation in cancer.” Wolfe, A.L; Singh, K.; Zhong, Y.; Drewe,P.; Rajsekhar, V.K.; Sanghvi, V.R.; Mavrakis, K.J.; Jiang, M.; Roderick, J.E.; Van der Meulen, J.; Schatz, J.H.; Rodrigo, C.M.; Zhao, C.; Rondou, P.; de Stanchina, E.; Teruya-Feldstein, J.; Kelliher, M.A.; Speleman, F.; Porco, J. A., Jr.; Pelletier, J.; Rätsch, G.; Wendel, H.G., Nature 2014, 453.
172. “Rapid Synthesis of Polyprenylated Acylphloroglucinol Analogs via Dearomative Conjunctive Allylic Annulation.” Grenning, A.J.; Boyce, J.H.; Porco, J.A. Jr., J. Am. Chem. Soc. 2014, 136, 11799-11804. Featured in C&EN, 2014, 92, 9.
171. “How proteins bind macrocycles.” Villar, E.A.; Beglov, D.; Chennamadhavuni, S.; Porco, J.A. Jr.; Kozakov, D.; Vajda, S.; Whitty, A., Nature Chemical Biology 2014, 53, 723-731.
170. “Asymmetric, Stereodivergent Synthesis of (−)-Clusianone Utilizing a Biomimetic Cationic Cyclization.” Boyce, J.H.; Porco, J.A. Jr., Angew. Chem. Int. Ed. 2014, 53, 7832-7837.
169. “Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes.” Martin, V.I.; Goodell, J.R.; Ingham, O.J.; Porco, J.A. Jr.; Beeler, A.B., J. Org. Chem. 2014, 79, 3838-3846. Highlighted in Derek Lowe’s blog ‘In the Pipeline’
168. “Total Synthesis and Stereochemical Assignment of (±)-Sorbiterrin A.” Qi, C.; Qin, T.; Suzuki, D.; Porco, J.A. Jr., J. Am. Chem. Soc. 2014, 136, 3374-3377. Featured in Nat. Chem. Bio., 2014, 10, 241. Highlighted in Synfacts, 2014, 10, 456.
167. “Total Syntheses of Secalonic Acids A and D.” Qin, T.; Porco, J.A. Jr., Angew. Int. Ed. 2014, 53, 3107-3110. Highlighted in Wezeman, T.; Masters, K.S.; Bräse, S. Angew. Int. Ed. 2014, 53, 4524-4526.
166. “Remodeling Natural Products: Chemistry and Serine Hydrolase Activity of a Rocoglate-Derived β-Lactone.” Lajkiewicz, N.J; Cognetta, A.B. III; Niphakis, M.J.; Cravatt, B.F.; Porco, J.A. Jr., J. Am. Chem. Soc. 2014, 136, 2659-2664.
165. “Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction.” Grenning, A.J.; Snyder, J.K.; Porco, J.A. Jr., Org. Lett. 2014, 16, 792-795.
2013
164. “Tandem Dienone Photorearrangement-Cycloaddition for the Rapid Generation of Molecular Complexity.” Bos, P.H.; Antalek, M.T.; Porco, J.A. Jr.; Stephenson, C.R.J., J. Am. Chem. Soc. 2013, 135, 17978-17982.
163. “Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia.” Nasr, Z.; Dow, L.E.; Paquet, M.; Chu, J.; Ravindar, K.; Somaiah, R.; Deslongchamps, P.; Porco, J.A. Jr.; Lowe, S.W.; Pelletier, J., BMC Pharmacology and Toxicology, 2013, 13, 1-12.
162. “Enantioselective Total Synthesis and Biological Evaluation of (+)-Kibdelone A and a Tetrahydroxanthone Analogue.” Winter, D.K.; Endoma-Arias, M.A.; Hudlicky, T.; Beutler, J.A.; Porco, J.A. Jr., J. Org. Chem. 2013, 78, 7617-7626.
161. “Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State.” Santagata, S.; Mendillo, M.L.; Tang, Y.-C.; Subramanian, A.; Perley, C.C.; Roche, S..; Wong, B.; Narayan, R.; Kwon, H.; Koeva, M.; Amon, A.; Golub, T.R.; Porco, J.A. Jr.; Whitesell, L.; Lindquist, S., Science 2013, 341, 1238303.
160. “Biomimetic Dehydrogenative Diels-Alder Cycloadditions: Total Syntheses of Brosimones A and B” Qi, C.; Cong, H.; Cahill, K. J.; Muller, P.; Johnson, R. P.; Porco, J. A. Jr., Angew. Chem. Int. Ed. 2013, 52, 8345-8348.
159. “Evidence for a Functionally Relevant Rocaglamide Binding Site on the elF4A-RNA Complex” Sadlish, H.; Galicia-Vazquez, G.; Paris, C.G.; Aust, T.; Bhullar, B.; Chang, L.; Helliwell, S.B.; Hoepfner, D.; Knapp, B.; Ridel, R.; Roggo, S.; Schuierer, S.; Studer, C.; Porco, J. A. Jr.; Pelletier, J.; Movva, N.R., ACS Chem. Biol. 2013, 8, 1519-1527.
158. “Metal-Catalyzed Cascade Rearrangements of 3-Alkynyl Flavone Ethers ” Xiong, Y.; Schaus, S.E.; Porco, J. A. Jr., Org. Lett. 2013, 15, 1962-1965.
157. “Polycyclic xanthone natural products: structure, biological activity and chemical synthesis” Winter, D.K.; Sloman, D.L.; Porco, J. A. Jr., Nat. Prod. Rep. 2013, 30, 382-391.
156. “eIF4F suppression in breast cancer affects maintenance and progression” Nasr, Z.; Robert, F.; Porco, J.A. Jr.; Muller, W.J.; Pelletier, J., Oncogene 2013, 861-871.
2012
155. “Synthesis of Chamaecypanone C Analogues from in Situ-Generated Cyclopentadienones and Their Biological Evaluation ” Dong, S.; Qin, T.; Hamel, E.; Beutler, J. A.; Porco, J. A. Jr., J. Am. Chem. Soc. 2012, 134, 19782-19787.
154. “Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations ” Leng, B.; Chichetti, S.; Su, S.; Beeler, A. B.; Porco, J. A. Jr., Beilstein Journal of Org. Chem. 2012, 8, 1338-1343.
153. “Development of an Alkaloid-Pyrone Annulation: Synthesis of Pleiomaltinine” Ziegler, R.E.; Tan, S.J.; Kam, T.S.; Porco, J.A. Jr., Angew. Chem. Int. Ed. 2012, 51, 9348-9351.
152. “Enantioselective Photocycloaddition of 3-Hydroxyflavones: Total Syntheses and Absolute Configuration Assignments of (+)-Ponapensin and (+)-Elliptifoline ” Lajkiewicz, N.J.; Roche, S.P.; Gerard, B.; Porco, J.A. Jr., J. Am. Chem. Soc. 2012, 134, 13108-13113. Highlighted in synfacts.
151. “Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein ” Jin, C.; Rodrigo, C.M.; Porco, J.A. Jr.; Kufe, D., Oncogene 2012, 2179-2188.
150. “Total Synthesis of Graphisin A and Sydowinin B” Little, A.; Porco, J.A. Jr., Org. Lett. 2012, 14, 2862-2865.
149. “Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis” Lin, C.J.; Nasr, Z.; Premsrirut, P.K.; Porco, J.A. Jr.; Hippo, Y.; Lowe, S.W.; Pelletier, J., Cell Rep. 2012, 4, 325-333.
148. “Studies Toward the Synthesis of the Epoxykinamycin FL-120B’: Discovery of a Decarbonylative Photocyclization” Scully, S.S.; Porco J.A. Jr., Org. Lett. 2012, 14, 2646-2649.
147. “Total Synthesis of (±)-Sorocenol B Employing Nanoparticle Catalysis” Cong, H.; Porco, J.A. Jr., Org. Lett. 2012, 14, 2516-2519.
146. “Total Synthesis of (±)-7-epi-Nemorosone” Zhang, Q.; Porco, J.A. Jr., Org. Lett. 2012, 14, 1797-1799.
145. “Synthesis of Azaphilone-Based Chemical Libraries” Achard, M.; Beeler, A.B.; Porco, J.A. Jr., ACS Comb. Sci 2012, 14, 236-244.
144. “Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis” Yeo, A. T.; Porco, J. A. Jr.; Gilmore, T. D. Cancer Letters 2012, 318, 53-60.
2011
143. “Development of a Photochemical microfluidics Platform ” Pimparkar, K.; Yen, B.; Goodell, J.R.; Martin, V.I.; Lee, W.H.; Porco, J. A. Jr.; Beeler, A.B.; Jensen, K.F. J. Flow Chem. 2011, 2, 53-55.
142. “Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies” Rodrigo, C.M.; Cencic, R.; Roche, S.P.; Pelletier, J.; Porco, J. A. Jr. J. Med. Chem. 2011, 558-562.
141. “Chemical Synthesis of Complex Molecules Using Nanoparticle Catalysis” Cong, H.; Porco, J. A. Jr. ACS Catal. 2011, 2, 65-70.
140. “Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro” Majumdara, I.D.; Devanabandaa, A.; Foxa, B.; Schwartzmana, J.; Cong, H.; Porco, J. A. Jr.; Weber, H.C. Biochem. Biophys. Res. Commun. 2011, 416, 397-402.
139. “Synthesis and Reactivity of Bicyclo[3.2.1] octanoid-Derived Cyclopropanes” Goodell, J. R.; Poole, J. L.; Beeler, A. B.; Aube, J.; Porco, J. A. Jr.; J. Org. Chem. 2011, 76, 9792-9800.
138. “Remodelling of the natural product fumagillol employing a reaction discovery approach” Balthaser, B. R.; Maloney, M. C.; Beeler, A. B.; Porco, J. A. Jr.; Snyder, J. K. Nature Chemistry 2011, 3, 969-973.
137. “Microwave-Based Reaction Screening: Tandem Retro-Diels–Alder/Diels–Alder Cycloadditions of o-Quinol Dimers”, Dong, S.; Cahill, K.J.; Kang, M.I.; Colburn, N.H.; Henrich, C.J.; Wilson, J.A.; Beutler, J.A.; Johnson, R.P.; Porco, J.A. Jr. J. Org. Chem., 2011, 76, 8944-8954.
136. “Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae)”, Ebada, S.S.; Lajkiewicz, N.; Porco, J.A. Jr.; Li-Weber, M.; Proksch, P. Progress in the Chemistry of Organic Natural Products, 2011, 94, 1-58.
135. “Asymmetric Total Synthesis of the Epoxykinamycin FL-120 B’ “, Scully, S.S.; Porco, J.A. Jr. Angew. Chem. Int. Ed., 2011, 50, 9722-9726.
134. “Targeting Cap-dependent Translation Blocks Converging Survival Signals by AKT and PIM Kinases in Lymphoma “, Schatz, J. H.; Orcchio E.; Wolfe A. L.; Jiang, M.; Linkov I.; Maragulia J.; Shi, W.; Zhang, Z.; Vinagolu, R. K.; Pagano, N. C.; Porco, J. A. Jr.; Teruya-Feldstein, J.; Rosen, N.; Pelletier, J.; Wendel, H.-G. J. Exp. Med., 2011, 208, 1799-1807.
133. “Gold Catalyzed Cyclization of Alkynes-Tethered Dihydropyrimidones”, Brown, L. E.; Dai, P.; Porco, J.A. Jr.; Schaus, S.E. Org. Lett., 2011, 13, 4228-4231.
132. “A Cycloisomerization/Friedel–Crafts Alkylation Strategy for the Synthesis of Pyrano[3,4-b]indoles”, Medeiros, M.R.; Schaus, S.E.; Porco, J.A. Jr. Org. Lett., 2011, 4012-4015.
131. “Total Synthesis and Absolute Stereochemical Assignment of Kibdelone C “, Sloman, D.L.; Bacon, J.W.; Porco, J.A. Jr. J. Am. Chem. Soc., 2011, 133, 9952-9955. Highligted in C&EN,
130. “Sequential Transformations to Access Polycyclic Chemotypes: Asymmetric Crotylation and Metal Carbenoid Reactions”, Wu, J.; Becerril, J.; Lian, Y.; Davies, H.M.L.; Porco, J.A. Jr.; Panek, J.S. Angew. Chem. Int. Ed., 2011, 50, 5938-5942.
129. “Dearomatization Strategies in the Synthesis of Complex Natural Products”, Roche, S.P.; and Porco, J.A. Jr. Angew. Chem. Int. Ed., 2011, 50, 4068-4093.
128. “Discovery of New Antimalarial Chemotypes Through Chemical Methodology and Library Development”, Brown, L.E.; Cheng, K.C.; Wei, W.; Yuan, P.; Dai, P.; Trillesa, R.; Ni, F.; Yuan, J.; MacArthur, R.; Guha, R.; Johnson, R.L.; Su, X.; Dominguez, M.M.; Snyder, J.K.; Beeler, A.B.; Schaus, S.E.; Inglese, J.; and Porco, J.A. Jr. P.N.A.S., 2011, 6775-6780.
127. “Synthesis of the Azaphilones (+)-Sclerotiorin and (+)-8-O-Methylsclerotiorinamine Utilizing (+)-Sparteine Surrogates in Copper-Mediated Oxidative Dearomatization”, Germain, A.R.; Bruggemeyer, D.M.; Zhu, J.; Genet, C.; O’Brien, P.; and Porco, J.A. Jr. J. Org. Chem., 2011, 76, 2577- 2584.
126. ” ESIPT-Mediated Photocycloadditions of 3-Hydroxyquinolinones: Development of a Fluoroescence Quenching Assay for Reaction Screening “, Xia, B.; Gerard, B.; Solano, D.M.; Wan, J.; Jones, G. II; and Porco, J.A. Jr. Org. Lett., 2011, 13, 1346-1349.
125. ”Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones”, Sloman, D.L.; Mitasev, B.; Scully, S.S.; Beutler, J.A.; and Porco, J.A. Jr. Angew. Chem. Int. Ed ., 2011, 50, 2511-2515.
124. ” Vinylogous Addition of Siloxyfurans to Benzopyryliums: A Concise Approach to the Tetrahydroxanthone Natural Products”, Qin, T.; Johnson, R. P.; and Porco, J.A. Jr. J. Am. Chem. Soc., 2011, 133, 1714–1717.
2010
123. ”Total Synthesis of Plukenetione A”, Zhang, Q; Mitasev, B.; Qi, J.; and Porco, J.A., Jr. J. Am. Chem. Soc. 2010, 132, 14212-14215.
122. ”Catalytic Enantioselective Alkylative Dearomatization-Annulation: Total Synthesis and Absolute Configuration Assignment of Hyperibone K”, Qi, J.; Beeler, A. B.; Zhang, Q.; and Porco, J.A., Jr. J. Am. Chem. Soc. 2010, 132, 13642-13644.
121. ”Biomimetic Photocycloaddition of 3-Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation “, Roche, S.P.; Cencic, R.; Pelletier, J.; and Porco, J.A., Jr. Angew. Chem. Int. Ed. 2010, 49, 6533-6538.
120. “Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones”, Goodell, J.R.; Leng, B.; Snyder, T. K.; Beeler, A. B; Porco, J. A., Jr. Synthesis 2010, 13, 2254-2270.
119. “Enantioselective Synthesis of 3,4-Chromanediones via Asymmetric Rearrangement of 3-Allyloxyflavones”, Marie, J.C.; Xiong, Y.; Min, G. K.; Yeager, A.R.; Taniguchi, T.; Berova, N.; Schaus, S.E.; Porco, J. A., Jr. J. Org. Chem. 2010, 75 ,4584–4590. Highlighted in synfacts.
118. “Skeletal Diversity via Cationic Rearrangements of Substituted Dihydropyrans”, Medeiros, M.R.; Narayan, R.S.; McDougal,
N.T.; Schaus, S.E.; Porco, J. A., Jr. Org. Lett. 2010, 12 , pp 3222–3225.
N.T.; Schaus, S.E.; Porco, J. A., Jr. Org. Lett. 2010, 12 , pp 3222–3225.
117. “Silver Nanoparticle-Catalyzed Diels-Alder Cycloadditions of 2′-Hydroxychalcones.” Cong, H.; Becker, C. F.; Elliott, S. J.; Grinstaff, M. W.; Porco, J. A., Jr. J. Am. Chem. Soc. 2010, 132, 7514-7518. Highlighted in C&EN and Science.
116. “Tandem Processes Identified from Reaction Screening: Nucleophilic Addition to Aryl N-Phosphinylimines Employing La(III)-TFAA Activation.” Kinoshita, H.; Ingham, J. O.; Ong, W. W.; Beeler, B. A.; Porco, J. A., Jr. J. Am. Chem. Soc. 2010, 132, 6412–6418.
115. “Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Polycyclic Iminium Ethers.” Treece, L. J. ; Goodell, R. J. ; Vender Velde, D. ; Porco, J. A., Jr.; Aube, J. J. Org. Chem. 2010, 75, 2028-2038.
114. “A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization,” Kota,S; Scampavia, L.; Spicer, T.; Beeler, A.B.; Takahashi, V.; Snyder, J.K.; Porco, J.A., Jr.; Hodder, P.; Strosberg, A.D. Assay Drug Dev. Technol., 2010, 8, 96-105.
113. “Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles.” Liang, B.; Kalidindi, S.; Porco, J. A., Jr.; Stephenson, C. R. Org. Lett. 2010, 12, 572-575.
112.“Synergistic Effect of Inhibiting Translation Initiation in Combination with Cytotoxic Agents in Acute Myelogenous Leukemia Cells” Cencic, R.; Carrier, M.; Trnkus, A.; Porco, J. A., Jr.; Minden, M.; Pelletier, J. Leukemia Res. 2010, 34, 535-541.
2009
111. “Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds” Goodell, J.R.; McMullen, J. P.; Zaborenko, N.; Maloney, J. R.; Ho, C.-X.; Jensen, K. F.; Porco, J. A., Jr.; Beeler, A. B. J. Org. Chem. 2009, 74, 6169-6180.
110. “Stereoselective Synthesis of Spirocyclic Oxindoles via Prins Cyclizations.” Castaldi,M.P.; Troast,D.M.; Porco, J. A., Jr. Org. Lett. 2009, 11, 3362-3365.
109. “Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol.” Cencic, R.; Carrier, M.; Galicia-Vázquez, G.; Bordeleau, M. E.; Sukarieh, R.; Bourdeau, A.; Brem, B.; Teodoro, J. G.; Greger, H.; Tremblay, M. L.; Porco, J. A., Jr.; Pelletier, J. PLoS ONE. 2009, 4, e5223.
108. “Manganese(III)-Mediated Transformations of Phloroglucinols: A Formal Oxidative [4 + 2] Cycloaddition Leading to Bicyclo[2.2.2]octadiones” Mitasev, B.; Porco, J. A., Jr. Org Lett. 2009, 11, 2285-2288.
107. “Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor” Dong, S.; Hamel, E.; Bai, R.; Covell, D. G.; Beutler, J. A.; Porco, J. A., Jr. Angew. Chem. Int. Ed. 2009, 48, 1494-1497.
106. “Reaction Discovery Employing Macrocycles: Transannular Cyclizations of Macrocyclic Bis-lactams” Han, C.; Rangarajan, S.; Voukides, A. C.; Beeler, A. B.; Johnson, R.; Porco, J. A., Jr. Org. Lett. 2009, 11, 413-416.
2008
105. “Studies toward the Synthesis of (-)-Zampanolide: Preparation of the Macrocyclic Core” Troast, D. M.; Yuan, J.; Porco, J. A., Jr. Adv. Synth. Catal. 2008, 350, 1701-1711.
104. “Electron Transfer-Initiated Diels-Alder Cycloadditions of 2′-Hydroxychalcones” Cong, H.; Ledbetter, D.; Rowe, G. T.; Caradonna, J. P.; Porco, J. A., Jr. J. Am. Chem. Soc. 2008, 130, 9214-9215.
103. “Therapeutic Suppression of Translation Initiation Modulates Chemosensitivity in a Mouse Lymphoma Model” Bordeleau, M-E.; Robert, F.; Gerard, B.; Lindqvist, L.; Chen, S. M. H.; Wendel, H-G.; Brem, B.; Greger, H.; Lowe, S. W.; Porco, J. A., Jr.; Pelletier, J. J. Clin. Invest. 2008, 118, 2651-2660.
102. “Applying Computer-Assisted Structure Elucidation Algorithms for the Purpose of Structure Validation: Revisiting the NMR Assignments of Hexacyclinol” Williams, A. J.; Elyashberg, M. E.; Blinov, K. A.; Lankin, D. C.; Martin, G. E.; Reynolds, W. F.; Porco, J. A., Jr.; Singleton, C. A.; Su, S. J. Nat. Prod. 2008, 71, 581-588.
101. “Enantioselective Synthesis of Bicyclo[2.2.2]octenones Using a Copper-Mediated Oxidative Dearomatization/[4 + 2] Dimerization Cascade” Dong, S.; Zhu, J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2008, 130, 2738-2739.
2007
100. “Structure-Activity Relationship Study of [1,2,3]thiadiazole Necroptosis Inhibitors” Teng, X.; Keys, H.; Jeevanandam, A.; Porco, J. A., Jr.; Degterev, A.; Yuan, J.; Cuny, G. D. Bioorg. Med. Chem. Lett. 2007, 17, 6836-6840.
99. “Preparation of Alkylidene Indane and Related Scaffolds and Their Further Elaboration to Novel Chemotypes” Kesavan, S.; Panek, J. S.; Porco, J. A., Jr. Org. Lett. 2007, 9, 5203-5206.
98. “1,2-Dihydroisoquinolines as Templates for Cascade Reactions To Access Isoquinoline Alkaloid Frameworks” Su, S.; Porco, J. A., Jr. Org. Lett. 2007, 9, 4983-4986.
97. “Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen.” Peng, L. A.; Kim, S. S.; Matchacheep, S.; Lei, X.; Su, S.; Lin, W.; Runguphan, W.; Choe, W-H.; Sakamoto, N.; Ikeda, M.; Kato, N.; Beeler, A. B.; Porco, J. A., Jr.; Schreiber, S. L.; Chung, R. T. Antimicrob. Agents Chemother. 2007, 51, 3756-3759.
96. “Rapid Access to Polyprenylated Phloroglucinols via Alkylative Dearomatization-Annulation: Total Synthesis (±)-Clusianone.” Qi, J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2007, 129, 12682-12683.
95. “Enantioselective Synthesis of the Complex Rocaglate (-)-Silvestrol.” Gerard, B.; Cencic, R.; Pelletier, J.; Porco, J.A., Jr. Angew. Chem. Int. Ed. Engl. 2007, 46, 7831-7834.
94. “Skeletal Diversity Through p-Radical Cyclization of Tetrahydropyridine Scaffolds.” Dandapani, S.; Dudata, M.; Panek, J. S.; Porco, J. A., Jr. Org. Lett. 2007, 9, 3849-3852.
93. “Nucleophilic Addition to N-Phosphinylimines via Rare Earth Metal Triflate / Trifluoroacetic Anhydride Activation.” Ong, W. W.; Beeler, A. B.; Kesavan, S.; Panek, J. S.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2007, 46, 7470-7472.
92. “Synthesis of Pyrrolo-isoquinolines Related to the Lamellarins Using Silver-Catalyzed Cycloisomerizaton/Dipolar Cycloaddition.” Su, S.; Porco, J. A., Jr. J. Am. Chem. Soc. 2007, 129, 7744-7745.
91. “An Approach to Skeletal Diversity Using Functional Group Pairing of Multifunctional Scaffolds.” Comer, E.; Rohan, E.; Deng, L.; Porco, J. A., Jr. Org. Lett. 2007, 9, 2123-2126.
90. “Organic Chemistry: Synthesis Undressed.” Porco, J. A., Jr. Nature 2007, 446 (7134), 383-385.
89. ”Stereochemical and Skeletal Diversity Employing Pipecolate Ester Scaffolds”, Yu, C.; Panek, J. S.; Porco, J. A. Jr, Org. Lett, 2007, 9, 1529-1532.
88. ”Synthesis of Carbamates and Ureas Using Zr(IV)-Catalyzed Exchange Processes.” Han, C.; Porco, J. A, Jr. Org. Lett. 2007, 9, 1517-1520
87. ”Discovery of Chemical Reactions through Multidimensional Screening.” Beeler, A. B.; Su, S.; Singleton, C. A.; Porco, J. A, Jr. J. Am. Chem. Soc. 2007, 129, 1413-1419.
86. ”Synthesis of 5,6,7,8-Tetrahydro-1,6-naphthyridines and Related Heterocycles by Cobalt-Catalyzed [2 + 2 + 2] Cyclizations.” Zhou, Y.; Porco, J. A, Jr.; Snyder, J. K. Org. Lett. 2007, 9, 393-396.
2006
85. ”Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening against GPCR Targets.” Dandapani, S.; Lan, P.; Beeler, A. B.; Beischel, S.; Abbas, A.; Roth, B. L.; Porco, J. A, Jr., Panek, J. S. J. Org. Chem. 2006, 71, 8934-8945.
84. ”Total Synthesis of the Diazobenzofluorene Antibiotic (-)-Kinamycin C1.” Lei, X.; Porco, J. A, Jr. J. Am. Chem. Soc. 2006, 128, 14790-14791 .
83. “Exploring Skeletal Diversity via Ring Contraction of Glycal-Derived Scaffolds.” Yeager, A. R.; Min, G. K.; Porco, J. A, Jr.; Schaus. S. E. Org. Lett. 2006, 8, 5065-5068.
82. “Asymmetric Syntheses of (-)-Mitorubrin and Related Azaphilone Natural Products.” Zhu, J.; Porco, J. A., Jr. Org. Lett. 2006, 8, 5169-5171.
81. “Total Synthesis and Structure Assignment of (+)-Hexacyclinol.” Porco, J. A., Jr.; Su, S.; Lei, X.; Bardhan, S.; Rychnovsky, S. D. Angew. Chem. Int. Ed. Engl. 2006, 45, 5790-5792.
80. “Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity – and high glucose-induced b cell dysfunction in isolated pancreatic islets.” Zhang, C-Y.; Parton, L. E.; Ye, C-P.; Krauss, S.; Shen, R.; Lin, C-T.; Porco, J. A., Jr.; Lowell.B. B. Cell Metabolism, 2006, 3, 417-427.
79. “Total Synthesis of the Interleukin-1 Converting Enzyme Inhibitor EI-1941-2 Using Tandem Oxa-electrocyclization/Oxidation 1.” Kleinke, A. S.; Li, C.; Rabasso, N.; Porco, J. A., Jr. Org. Lett, 2006, 8, 2857-2850.
78. “Enantioselective Photocycloaddition Mediated by Chiral Br nsted Acids: Asymmetric Synthesis of the Rocaglamides.” Gerard, B.; Sangji, S.; O’Leary, D. J.; Porco, J. A., Jr. J. Am. Chem. Soc, 2006, 128, 7754-7755.
77. “Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes.” Gerard, B.; Ryan, J.; Beeler, A. B.; Porco, J. A., Jr. Tetrahedron 2006, 62, 6405-6411.
76. “Targeting Heat Shock Response to Sensitize Cancer Cells to Proteasome and Hsp90 Inhibitors.” Zaarur, N.; Gabai, V. L.; Porco, J. A., Jr.; Calderwood, S.; Sherman, M. Y. Cancer Research 2006, 66, 1783-1791.
75. “Total Synthesis and Stereochemical Assignment of the Spiroisoxazoline Natural Product (+)-Calafianin.” Bardhan, S.; Schmitt, D. C.; Porco, J. A., Jr. Org. Lett. 2006, 8, 927-930.
74. “A µ-η2:η2 -Disulfide Dicopper( II ) Complex from Reaction of S8 with a Copper( I ) Precursor: Reactivity of the Bound Disulfur Moiety.” Helton, M. E.; Maiti, D; Zakharov, L. N.; Rheingold, A. L.; Porco, J. A., Jr.; Karlin, K. D. Angew. Chem. Int. Ed. Engl. 2006, 45, 1138-1141.
73. “Inhibition of transcription factor NF-kB signaling proteins IKKb and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity.” Liang, M-C.; Bardhan, S.; Pace, E. A.; Rosman, D.; Beutler, J. A.; Porco, J. A., Jr.; Gilmore, T. D. Biochemical Pharmacology 2006, 71, 634-645.
72. “The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an I[kappa]B[alpha]-deficient diffuse large B-cell lymphoma cell line.” Liang, M-C. Bardhan, S.; Porco, J. A., Jr.; Gilmore, T. D. Cancer Letters 2006, 241, 69-78.
2005
71. “Enantioselective Synthesis of Linear Polypropionate Arrays Using Anthracene-Tagged Organosilanes." Kesavan, S.; Su, Q.; Shao, J.; Porco, J. A., Jr.; Panek, J. S. Org. Lett. 2005, 7, 4435-4438.
70. “Synthesis of a Library of Complex Macrodiolides Employing Cyclodimerization of Hydroxy Esters.” Beeler, A. B.; Acquilano, D. E.; Su, Q.; Yan, F.; Roth, B. L.; Panek, J. S.; Porco, J. A., Jr. J. Comb. Chem. 2005, 7, 673-681.
69. “Stereocontrolled Synthesis of a Complex Library via Elaboration of Angular Epoxyquinol Scaffolds.” Lei, X.; Zaarur, N.; Sherman, M. Y.; Porco, J. A., Jr. J. Org. Chem. 2005, 70, 6474-6483.
68. “Synthesis of Epoxyquinol A and Related Molecules: Probing Chemical Reactivity of Epoxyquinol Dimers and 2H-Pyran Precursors.” Li, C.; Porco, J. A., Jr. J. Org. Chem. 2005, 70, 6053-6065.
67. “Catalytic Ester-Amide Exchange Using Group(IV) Metal Alkoxide-Activator Complexes.” Han, C.; Lee, J. P.; Lobkovsky, E.; Porco, J. A., Jr. J. Am. Chem. Soc. 2005, 127, 10039-10044.
66. “Synthesis of the Azaphilones Using Copper-Mediated Enantioselective Oxidative Dearomatization.” Zhu, J.; Grigoriadis, N. P.; Lee, J. P.; Porco, J. A., Jr. J. Am. Chem. Soc. 2005, 127, 9342-9343.
65. “Convergent Synthesis of a Complex Oxime Library Using Chemical Domain Shuffling.” Su, S.; Acquilano, D. E.; Arumugasamy, J.; Beeler, A. B.; Eastwood, E. L.; Giguere, J. R.; Lan, P.; Lei, X.; Min, G. K.; Yeager, A. R.; Zhou, Y.; Panek, J. S.; Snyder, J. K.; Schaus, S. E.; Porco, J. A., Jr. Org. Lett. 2005, 7, 2751-2754.
64. “Chemical library synthesis using convergent approaches,” Beeler, A. B.; Schaus, S.E.; Porco, J.A. Jr. Curr. Opin. Chem. Biol., 2005, 9, 277-284.
63. “Synthesis of the Tetracyclic Core of the Tetrapetalones through Transannular Oxidative [4+3] Cyclization.” Wang, X.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2005, 44, 3067-3071.
62. “Synthesis of Photoactivatable Acyclic Analogues of the Lobatamides.” Shen, R.; Inoue, T.; Forgac, M.; Porco, J. A., Jr. J. Org. Chem. 2005, 70, 3686-3692.
2004
61. “A Biomimetic Approach to the Rocaglamides Employing Photogeneration of Oxidopyryliums Derived from 3-Hydroxyflavones.” Gerard, B.; Jones, G., II.; Porco, J. A., Jr. J. Am. Chem. Soc. 2004, 126, 13620-13621.
60. “Synthesis of complex alkoxyamines using a polymer-supported N-hydroxyphthalimide.” Su, S.; Giguere, J. R.; Schaus, S. E.; Porco, J. A., Jr. Tetrahedron 2004, 60, 8645-8657.
59. “Total Synthesis of the Salicylate Enamide Macrolide Oximidine III: Application of Relay Ring-Closing Metathesis.” Wang, X.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2004, 43, 3601-3605.
58. “Synthesis of Azaphilones and Related Molecules by Employing Cycloisomerization of o-Alkynylbenzaldehydes.” Zhu, J.; Germain, A. R.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2004, 43, 1239-1243.
57. “Synthesis of a Polymer-Supported Anthracene and Its Application as a Dienophile Scavenger.” Lei, X.; Porco, J. A., Jr.; Org. Lett. 2004, 6, 795-798.
56. “Synthesis of the Epoxyquinol Dimer RKB-3564 D : Utilization of an Alkoxysilanol To Promote [4 + 4] Dimerization.” Li, C.; Porco, J. A., Jr.; J . Am. Chem. Soc. 2004, 126, 1310-1311.
55. “Copper-Mediated Synthesis of N-Acyl Vinylogous Carbamic Acids and Derivatives: Synthesis of the Antibiotic CJ-15,801.” Han, C.; Shen, R.; Su, S.; Porco, J. A., Jr.; Org. Lett. 2004, 6, 27-30.
2003
54. “Polymer-Assisted Solution-Phase (PASP) Suzuki Couplings Employing an Anthracene-Tagged Palladium Catalyst.” Lan, P.; Berta, D.; Porco, J. A., Jr.; South, M. S.; Parlow, J. J.; J. Org. Chem. 2003; 68, 9678-9686.
53. “The Development of a Chromatography-Free Mitsunobu Reaction: Synthesis and Applications of an Anthracene-Tagged Phosphine Reagent.” Lan, P.; Porco, J. A., Jr.; South, M. S.; Parlow, J. J. J. Comb. Chem. 2003, 5, 660-669.
52. “Total Synthesis of the Ubiquitin-Activating Enzyme Inhibitor (+)-Panepophenanthrin.” Lei, X.; Johnson, R. P.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2003, 42, 3913-3917.
51. “Stereochemical Diversity through Cyclodimerization: Synthesis of Polyketide-like Macrodiolides.” Su, Q.; Beeler, A. B.; Lobkovsky, E.; Porco, J. A., Jr.; Panek, J. S. Org. Lett, 2003, 5, 2149-2152.
50. “Synthesis and Cell Cycle Inhibition of the Peptide Enamide Natural Product Terpeptin and the Aspergillamides.” Su, S.; Kakeya, H.; Osada, H.; Porco, J. A., Jr. Tetrahedron, 2003, 59, 8931-8946.
49. “Jesterone Dimer, a Synthetic Derivative of the Fungal Metabolite Jesterone, Blocks Activation of Transcription Factor Nuclear Factor kB by Inhibiting the Inhibitor of kB Kinase,” Liang, M.-C.; Bardhan, S.; Li, C.; Pace, E. A.; Porco, J. A., Jr.; Gilmore, T. D. Molecular Pharmacology, 2003, 64, 123-131.
48. “Lobatamide C: Total Synthesis, Stereochemical Assignment, Preparation of Simplified Analogues, and V-ATPase Inhibition Studies.” Shen, R.; Lin, C. T.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 7889-7901.
47. “Total Synthesis of the Salicylate Enamide Macrolide Oximidine II.” Wang, X.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 6040-6041.
46. “Total Synthesis of the Quinone Epoxide Dimer (+)-Torreyanic Acid: Application of a Biomimetic Oxidation/Electrocylization/Diels-Alder Dimerization Cascade.” Li, C.; Johnson, R. P.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 5095-5106.
2002
45. “Angiogenesis Inhibitor Epoxyquinol A: Total Synthesis and Inhibition of Transcription Factor NF-kB.” Li, C.; Bardhan, S.; Pace, E. A.; Liang, M.-C.; Gilmore, T. D.; Porco, J. A., Jr. Org. Lett. 2002, 4, 3267-3270.
44. “Synthesis and V-ATPase Inhibition of Simplified Lobatamide Analogues.” Shen, R; Lin, C. T.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. Org. Lett. 2002, 4, 3103-3106.
43. “Polymer-assisted parallel solution phase synthesis of substituted benzimidazoles.” Yun, Y. K.; Porco, J. A., Jr.; Labadie, J. Synlett. 2002, 5, 739-742.
42. “Total Synthesis and Stereochemical Assignment of the Salicylate Antitumor Macrolide Lobatamide C.” Shen, R.; Lin, C. T.; Porco, J. A., Jr. J. Am. Chem. Soc. 2002, 124, 5650-5651.
41. “Studies Toward the Synthesis of (-)-Zampanolide: Preparation of N-Acyl Hemiaminal Model Systems.” Troast, D. M.; Porco, J. A., Jr. Org. Lett. 2002, 4, 991-994.
2001
40. “Total Synthesis of the NF-kB Inhibitor (-)-Cycloepoxydon: Utilization of Tartrate-Mediated Nucleophilic Epoxidation.” Li, C.; Pace, E. A.; Liang, M-C.; Lobkovsky, E.; Gilmore, T. D.;. Porco, J. A., Jr. J. Am. Chem. Soc. 2001, 123, 11308-11309.
39. “Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold.” Kulkarni, B. A.; Roth, G. P.; Lobkovsky, E.; Porco, J. A., Jr. J. Comb. Chem. 2002, 4, 56-72.
38. “Modification of C-Terminal Peptides for Form Peptide Enamides: Synthesis of Chondriamides A and C.” Wang, X.; Porco, J. A., Jr. J. Org. Chem.. 2001, 66, 8215-8221
37. “Exploring Chemical Diversity of Epoxyquinoid Natural Products: Synthesis and Biological Activity of (-)-Jesterone and Related Molecules.” Hu, Y.; Li, C.; Kulkarni, B.; Strobel, G.; Lobkovsky, E.; Porco, J. A. , Jr. Org. Lett. 2001, 3, 1649-1652.
2000
36. “Total Synthesis of (±) Torreyanic Acid.” Li, C.; Lobkovsky, E.; Porco, J. A., Jr. J. Am. Chem. Soc. 2000, 122, 10484-10485.
35. “Parallel Synthesis and Purification using Anthracene-Tagged Substrates.” Wang, X.; Parlow, J. J.; Porco, J. A., Jr. Org. Lett. 2000, 2, 3509-3512.
34. “Multistep Synthesis of 1,2,3-Thiadiazoles using ‘Catch and Release’.” Hu, Y.; Baudart, S.; Porco, Jr., J. A. High Throughput Synthesis: Theory and Practice, Chapter 6, Section 5, (Sucholeiki, I., editor), Marcel Dekker, NY, 2000.”
33. “Synthesis of Enamides Related to the Salicylate Antitumor Macrolides Using Copper-mediated Vinylic Substitution.” Shen, R.; Porco, J. A., Jr. Org. Lett. 2000, 2, 1333-1336.
32. “Organic Synthesis Using Chemical Tags: The ‘Third Leg’ of Parallel Synthesis.” Porco, J. A., Jr. Combinatorial Chemistry and High Throughput Screening, 2000, 3, 93-102.
31. “Streamlined Synthesis of Substituted 2-Aminothiazoles Using Tandem Precipitative and Polymer-Assisted Reactions.” Yun, Y. K.; Leung, S. S. W.; Porco, J. A., Jr. Biotechnol. Bioeng. 2000, 71, 9-18.